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PYRIMIDINE DIMERS
Descriptors Found:
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DeCS
Descriptor
English
:
Pyrimidine Dimers
Descriptor
Spanish
:
Dímeros de Pirimidina
Descriptor
Portuguese
:
Dímeros de Pirimidina
Synonyms
English
:
Thymine Dimers
Tree Number:
D03.383.742.686.600
D13.695.578.424.600
D13.695.740.600
Definition
English
:
Dimers found in DNA chains damaged by
ULTRAVIOLET RAYS
. They consist of two adjacent
PYRIMIDINE NUCLEOTIDES
, usually
THYMINE nucleotides
, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block
DNA REPLICATION.
See Related
English
:
DNA Damage
History Note
English
:
77
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
12177
Unique Identifier:
D011740
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS